In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Hydroxychloroquine overdose Skin discoloration plaquenil Hydroxychloroquine arthritis mechanism Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Hydroxychloroquine use in children younger than 7 may be limited by the difficulty in obtaining satisfactory evaluation of color vision in this age group. Therefore, children taking HCQ should receive an annual ophthalmologic examination. Other rare side effects include changes in skin pigmentation and cardiomyopathy diseases of the heart muscle. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine pigmentation Hydroxychloroquine-Associated Hyperpigmentation. - PubMed Central PMC, Hydroxychloroquine DermNet NZ Lose weight after plaquenil Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Plaquenil Side Effects Common, Severe, Long Term -. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Skin Discoloration and Plaquenil - Arthritis Information. Drug-induced pigmentation is not generally associated with any systemic toxicity and thus has an excellent prognosis. With some exceptions, pigmentation is usually reversible and slowly fades with discontinuation of the drug. The imputability of hydroxychloroquine in the genesis of this discoloration is difficult to establish. Our study supports the hypothesis that ecchymosis, platelet antiaggregants and oral anticoagulants may be the main predisposing factors to hydroxychloroquine-induced pigmentation. Skin Hyperpigmentation with Hydroxychloroquine. Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus.