Plaquenil toxicity cumulative dose

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  1. Deemik New Member

    Plaquenil toxicity cumulative dose


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Cumulative use in excess of 250 grams increases the risk for toxic retinopathy. Other risk factors include obesity, kidney or liver disease, older age. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1% after long-term or a cumulative dosage of 1,000mg. 3 The toxicity would double by 10 years. There is an increased risk of HCQ retinopathy with increase in the cumulative dose. Per the prior 2011 AAO guidelines the recommended maximum dose to minimize HCQ retinal toxicity was 6.5 mg /kg based on ideal body weight 2. The advantage of the real body weight formula is that it distributes the risk evenly on a broad range of body habitus.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil toxicity cumulative dose

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  4. The estimated risk of hydroxychloroquine retinopathy in patients on chronic hydroxychloroquine therapy ranges from 0.4% to 8.0%. 1 Toxicity is thought to be dependent on cumulative total dose. 3 Additional factors that can precipitate early toxicity are concomitant renal disease and use of tamoxifen. 3

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    A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. The Hydroxychloroquine Dosing Calculator calculates appropriate daily dose of hydroxychloroquine. Calc Function ; Calcs that help predict probability of a disease Diagnosis. Subcategory of 'Diagnosis' designed to be very sensitive Rule Out. Disease is diagnosed prognosticate to guide treatment Prognosis. A cumulative dose that increases the risk of retinal toxicity • 1000g total Hydroxychloroquine HCQ • 460 g total Chloroquine CQ Cumulative dose of 1000g HCQ is reached in 7 years with the daily dose of 400mg19 Cumulative dose of 460g CQ is reached in 5 years with the typical daily dose of 250mg19

     
  5. smru User

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Study of the Efficacy of Chloroquine in the Treatment of. Chloroquine - Wikipedia PDF JNK inhibitors is there a future? Jonas Cicenas.
     
  6. Enio Well-Known Member

    In some cases, they may not be available in every strength or form as the brand-name drug. Can You Drink Alcohol If You Have Rheumatoid Arthritis. Can i Drink Alcohol While Taking Plaquenil - JustAnswer Plaquenil and drinking - Sjogren's World
     
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    Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used.

    Sjogren's and Tendonitis, bursitis, torn Achilles and so on.
     
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    Hydroxychloroquine effectiveness in reducing symptoms of hand. Mar 02, 2013 Background. Osteoarthritis OA is an increasingly common problem in ageing Western societies, affecting an estimated 8.5 million people in the UK and causing both an enormous burden to health systems and considerable pain and disability to affected individuals 1, 2. Although radiographic hand OA.

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