Chloroquine diphosphate salt solubility

Discussion in 'Canadian Pharcharmy' started by lsergel, 11-Mar-2020.

  1. Coder_ak User

    Chloroquine diphosphate salt solubility


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Soluble in water Applications Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. Chloroquine phosphate Drug Entry Chloroquine. Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. 4 It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. 17. Chloroquine was granted FDA Approval on 31 October. The Chloroquine base also goes by the name; 7-chloro-4-4- diethylamino-1-methylbutylamino quinolone. The most commonly available version of the drug for aquarium use is the diphosphate salt. This compound is a fine white fine powder that is readily soluble in water.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine diphosphate salt solubility

    Chloroquine diphosphate C18H32ClN3O8P2 ChemSpider, Chloroquine phosphate - DrugBank

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  7. Sasaki et al 2010 Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 10 370 PMID 20630104. If you know of a relevant reference for Chloroquine diphosphate, please let us know.

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    Chloroquine is used as an drug to treat and prevent mainly malaria. Malaria is one of leading re-emerging infectious disease due to murative malarial parasite developed resistance to chloroquine. Sulfadoxine-pyrimethamine is an alternative can be used in the treatment of the disease resistant to chloroquine, but resistance to sulfadoxine. Chloroquine diphosphate salt C6628 - Product Information Sheet Author Sigma-Aldrich Corp. Subject This product is a member of the quinoline family with multiple applications. It was originally used as an antimalarial compound. Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death.

     
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    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Feb 19, 2020 Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days.

    Hydroxychloroquine Plaquenil
     
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    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses