Few adequate, well-controlled studies evaluating the potential for metabolic and/or pharmacologic interactions between botanicals and COUMADIN exist. Due to a lack of manufacturing standardization with botanical medicinal preparations, the amount of active ingredients may vary. Massive hydroxychloroquine overdose Od symptoms for plaquenil Hydroxychloroquine 200 mg daily One of the most serious side effects is a toxicity in the eye generally with chronic use. People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. Summary Drug interactions are reported among people who take Plaquenil and Coumadin together. This study is created by eHealthMe based on reports of 920 people who take Plaquenil and Coumadin from Food and Drug Administration FDA, and is updated regularly. A list of drugs that interact with Hydroxychloroquine. Hydroxychloroquine is predicted to increase the risk of haematological toxicity when given with penicillamine. Monitor the patient's response with additional INR determinations when initiating or discontinuing any botanicals. This could further confound the ability to assess potential interactions and effects on anticoagulation. Warfarin interaction with hydroxychloroquin Interactions between Travel Vaccines & Drugs - Chapter 2., Plaquenil and Coumadin drug interactions - eHealthMe Plaquenil for autoimmune disordersPlaquenil eye exam njCan plaquenil effect narcolepsyWhat are the side effects of taking plaquenil Drug Interaction Classification Systems Significance Rating A Criteria Management Rating B Criteria 0 Not listed 0 Not listed 1 Severity - Major The effects are potentially life-threatening or capable of causing permanent damage. Warfarin drug interactions Anticoagulation Services. Hydroxychloroquine Interactions BNF content published by NICE. Warfarin and Alcohol / Food Interactions -. Summary Drug interactions are reported among people who take Warfarin sodium and Plaquenil together. This study is created by eHealthMe based on reports of 204 people who take Warfarin sodium and Plaquenil from Food and Drug Administration FDA, and is updated regularly. Despite the availability of evidence of the interaction between acetaminophen and warfarin since the 1960s, data concerning the clinical significance of the interaction remains scarce. Recommendations regarding the management of patients taking both drugs are not strong because no studies examining outcomes, such as major bleeding, exist. Hydroxychloroquine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works.