Try refreshing the page, or returning to the homepage. If the problem continues, please visit our support portal. Hydroxychloroquine interaction with gabapentin Plaquenil consumer medicine information Bull's-eye maculopathy due to hydroxychloroquine toxicity. Contributor Jesse Vislisel, MD Photographer Randy Verdick, FOPS September 9, 2013. This patient took hydroxychloroquine for rheumatoid arthritis and her vision dropped to 20/300 as a result of the retinal toxicity. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Retinal toxicity has been shown in patients taking greater than 3 mg/kg/day of chloroquine or 6.5 mg/kg/day of hydroxychloroquine. While most cases of toxicity have been reported for chloroquine, hydroxychloroquine has supplanted it as the more commonly used treatment agent for both RA and SLE. 2 Please review the following URL and make sure that it is spelled correctly. The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Macular oct plaquenil toxicity Plaquenil Toxicity - Bennett & Bloom Eye Centers, The Risk of Retinal Toxicity with Plaquenil Chloroquine side effects psoriasisPharmacokinetics of chloroquine phosphate The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Plaquenil Risk Calculators. Common Medications That May Be Toxic to the Retina. Retinal Physician - Hydroxychloroquine Maculopathy An Update.. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Patients with renal or hepatic dysfunction are at an increased risk of toxicity. 1 Other risk factors for retinal toxicity include short stature, obesity, advanced age and/or a pre-existing macular pathology. 1 So, what does this mean for our patient? Are the retinal changes a result of Plaquenil use? Ocular Surgery News The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients.