In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data (concentrations being 5 to 10 times higher). Ankylosing spondylitis hydroxychloroquine Trametinib hydroxychloroquine Aug 25, 2019 Prolonged half life of several weeks 50% of chloroquine is excreted unchanged; Resuscitation Coma Prompt intubation and ventilation, if acidaemia exists, give sodium bicarbonate 1 – 2 mmol/Kg IV to prevent further toxicity during intubation. End goals should be a narrow QRS 100ms and a pH 7.45 Desethylchloroquine and bisdesethylchloroquine concentrations reach 40 and 10% of chloroquine concentrations, respectively; both chloroquine and desethylchloroquine concentrations decline slowly, with elimination half-lives of 20 to 60 days. Both parent drug and metabolite can be detected in urine months after a single dose. Chloroquine has a long half-life, which can vary between 74 hours and 50 days, depending on the cumulative dose. The drug can remain in the skin for 6–7 months after the cessation of therapy. Chloroquine dosing. Chloroquine phosphate is dispensed as a 250 mg tablet, which is equivalent to 155 mg chloroquine base. Following administration chloroquine is rapidly dealkylated via cytochrome P450 enzymes (CYP) into the pharmacologically active desethylchloroquine and bisdesethylchloroquine. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. Half life of chloroquine Chloroquine - FDA prescribing information, side effects., Clinical Pharmacokinetics and Metabolism of Chloroquine SpringerLink Ulcer plaquenil A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine Indications, Side Effects, Warnings -. Chloroquine DermNet NZ. Chloroquine - Wikipedia. Half-life time of this drug is approximately 18 hours in vivo due to the degradation by the liver, but the stability of chloroquine in vitro experiments is expected to be longer. The plasma half-life of chloroquine in healthy individuals is generally reported to be 72-120 hr. In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug. For treatment of acute attacks of malaria in adults, one dose is usually taken right away, followed by half the dose 6 to 8 hours later and then half the dose once a day for the next 2 days. For prevention and treatment of malaria in infants and children, the amount of chloroquine phosphate is based on the child's weight.