Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine sulfate and sun exposure Chloroquine mechanism in the body We show that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle. Furthermore, CQ induces an autophagy-independent severe disorganization of the Golgi and endo-lysosomal systems, which might contribute to the fusion impairment. Chloroquine is widely distributed to body tissues as well as its analogue hydroxychloroquine. The concentration of hydroxychloroquine in the brain is 4–30 times higher than in the plasma 46. The concentration of chloroquine in the plasma reached 10 μM when a daily intake of 500 mg was prescribed to arthritis patients 47. Li, X. Lee, Y. Kang, Y. et al. Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine inhibits autophagy in host tissues Chloroquine in Cancer Therapy A Double-Edged Sword of., Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika. How to bill for plaquenil visual fieldPlaquenil tablet imageAralen doseHow long for plaquenil to lighten skin Chloroquine has a very high volume of distribution, as it diffuses into the body's adipose tissue. Chloroquine and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times. Chloroquine - Wikipedia. Hypoxia-induced autophagy of stellate cells inhibits.. Hexokinase II inhibitor, 3-BrPA induced autophagy by.. We have explored the ability of hydroxychloroquine HCQ, which inhibits autophagy, to affect antiestrogen responsiveness. Experimental Design TAM-resistant MCF7-RR and ICI-resistant/TAM cross-resistant LCC9 ER+ breast cancer cells were injected into mammary fat pads of female athymic mice and treated with TAM and/or ICI in combination with oral low-dose HCQ. Previous reports have described autophagy dependency of tumors in genetically engineered mouse models harboring deletions of Atg5 or Atg7. In most of these contexts, both tumor and normal host tissues are deficient for autophagy. As autophagy is highly stimulated during Acanthamoeba encystation, and chloroquine inhibits autophagy, this led us to speculate that chloroquine could possess a therapeutic role in the treatment of Acanthamoeba by blocking the processes in the autophagic pathway.