Chloroquine inhibits autophagy in host tissues

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  1. Shoorf User

    Chloroquine inhibits autophagy in host tissues


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    Hydroxychloroquine sulfate and sun exposure Chloroquine mechanism in the body

    We show that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle. Furthermore, CQ induces an autophagy-independent severe disorganization of the Golgi and endo-lysosomal systems, which might contribute to the fusion impairment. Chloroquine is widely distributed to body tissues as well as its analogue hydroxychloroquine. The concentration of hydroxychloroquine in the brain is 4–30 times higher than in the plasma 46. The concentration of chloroquine in the plasma reached 10 μM when a daily intake of 500 mg was prescribed to arthritis patients 47. Li, X. Lee, Y. Kang, Y. et al. Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine inhibits autophagy in host tissues

    Chloroquine in Cancer Therapy A Double-Edged Sword of., Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika.

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  6. Chloroquine has a very high volume of distribution, as it diffuses into the body's adipose tissue. Chloroquine and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times.

    • Chloroquine - Wikipedia.
    • Hypoxia-induced autophagy of stellate cells inhibits..
    • Hexokinase II inhibitor, 3-BrPA induced autophagy by..

    We have explored the ability of hydroxychloroquine HCQ, which inhibits autophagy, to affect antiestrogen responsiveness. Experimental Design TAM-resistant MCF7-RR and ICI-resistant/TAM cross-resistant LCC9 ER+ breast cancer cells were injected into mammary fat pads of female athymic mice and treated with TAM and/or ICI in combination with oral low-dose HCQ. Previous reports have described autophagy dependency of tumors in genetically engineered mouse models harboring deletions of Atg5 or Atg7. In most of these contexts, both tumor and normal host tissues are deficient for autophagy. As autophagy is highly stimulated during Acanthamoeba encystation, and chloroquine inhibits autophagy, this led us to speculate that chloroquine could possess a therapeutic role in the treatment of Acanthamoeba by blocking the processes in the autophagic pathway.

     
  7. KupuJIJI Well-Known Member

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. What is chloroquine made out of? AnswersDrive Chloroquine for research Cell-culture tested InvivoGen Chloroquine diphosphate salt - Sigma-Aldrich
     
  8. Pacak Moderator

    Antimalarial drugs Mode of action and status of resistance Mechanism of action and resistance, as well as status of resistance. studies indicated that chloroquine resistance was CHLOROQUINE Chloroquine was first synthesized in Germany, but it was not recognized as a potent antimalarial drug until the 1940s during the US World War II military effort. By 1946,

    Chloroquine Oral Route Proper Use - Mayo Clinic
     
  9. q-2007-2 New Member

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More