Chloroquine and p62

Discussion in 'Canadian Online Pharmacies' started by AlMot, 05-Mar-2020.

  1. gooverup XenForo Moderator

    Chloroquine and p62


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Each Premo™ Autophagy Sensor GFP-p62 Kit includes a vial of chloroquine diphosphate. Chloroquine has been demonstrated to inhibit autophagy by elevating lysosomal pH and therefore inhibiting the fusion of autophagosomes with lysosomes and preventing the subsequent lysosomal protein degradation. Moreover, elevated p62 is significantly correlated with poor survival in breast cancer patients Supplementary Figure 1, suggesting a role for autophagy in breast cancer reoccurrence 14-18. HCQ is a lysotropic chloroquine derivative that accumulates within lysosomes, resulting in lysosome neutralization and the inhibition of autophagic flux. Ab155686 staining SQSTM1/p62 autophagosome in control HeLa cells treated with ethanol 0.1% left panels and SQSTM1/p62 in HeLa cells treated with 1uM bafilomycin A1 for 18hrs right panels. The cells were fixed with methanol 5min, permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine and p62

    Frontiers Re-purposing Chloroquine for Glioblastoma., Hydroxychloroquine inhibits autophagy to potentiate.

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  4. P62/SQSTM1 Antibody NBP1-48320 HeLa cells were treated with + or without - 50 uM of Chloroquine for 24 hours and the whole cell lysates were analyzed in WB using anti-p62/SQSMT1 and anti-alpha tubulin NB100-690; loading control.

    • FAQs - Autophagy and LC3.
    • Anti-SQSTM1 / p62 antibody ab155686 Abcam.
    • CST - SQSTM1/p62 D5L7G Mouse mAb.

    Through the detection of autophagy substrates p62 and LC3, found that QBC939 cells have a higher flow of autophagy, autophagy inhibitor chloroquine can significantly increase the sensitivity of cisplatin in cholangiocarcinoma cells compared with hepatocellular carcinoma HepG2 cells. The p62 protein recognizes toxic cellular waste, which is then scavenged by a sequestration process known as self-eating or autophagy. Lack of autophagy leads to accumulation of p62, which is not. Antimalarial drug chloroquine inhibits autophagy of glioma cells and has been tested as an antineoplastic agent in a small clinical study 25. 10 nM Baf A1 for 2 hours, lysed, and analyzed by immunoblot for p62, an LC3-binding protein and marker of autophagic flux. Degradation of p62 indicates induction of autophagy. b-Tubulin shown as a.

     
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  6. Professor85 Guest

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Evidence of transplacental passage of hydroxychloroquine in. Hydroxychloroquine - Side Effects, Dosage, Interactions. Safety of Immunosuppressive Drugs. - PubMed Central PMC
     
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