One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine stock concentration Chloroquine retroviral transfection Any side effects from stopping plaquenil What plaquenil used for Mar 15, 2019 Published March 15, 2019 Spotting the Telltale Signs of Plaquenil Toxicity Subtle but characteristic alterations on OCT are often your first clue. RO Staff Chloroquine overdoses cause serious rapid symptomatology, with symptoms frequently seen within 30 minutes. Death is usually within 1 to 3 hours of ingestion and the cause is cardiac arrest. Drowsiness, dizziness, and visual disturbances can progress quickly to seizures, apnea, arrhythmias, and hypotension. Jivrajka RV, Genead MA, McAnany JJ, Chow CC, Mieler WF. Microperimetric sensitivity in patients on hydroxychloroquine Plaquenil therapy. Eye Lond 2013;27 91044-1052. Martinez-Costa L, Victoria Ibanez M, Murcia-Bello C, et al. Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Signs of plaquenil overdose Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Treatment of hydroxychloroquine overdose - ScienceDirect Hydroxychloroquine 200mg equivalentChloroquine and bacterial resistance Ophthalmologists should use Humphrey visual field test and OCT — and fundus autofluorescence if available can help, too — to detect signs of HCQ toxicity, Moshfeghi said. Despite Plaquenil dosing recommendations, retinal toxicity.. Multimodal Imaging in Plaquenil Toxicity. Plaquenil Uses, Dosage & Side Effects -. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Jun 30, 2015 Take this medication with a meal or a glass of milk to prevent stomach upset. Common side effects include nausea, loss of appetite, headache, and diarrhea. Plaquenil can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how it affects you. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible.