Retinal toxicity from plaquenil years after discontinued

Discussion in 'Canada Pharmacy' started by Valad, 29-Feb-2020.

  1. menedzher Well-Known Member

    Retinal toxicity from plaquenil years after discontinued

    Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology.

    Hydroxychloroquine manufacturer not work Hydroxychloroquine tablets ip Plaquenil changed your hair

    Similarly, concomitant retinal conditions predispose to toxicity due to predamaged cellular elements. At recommended doses, the risk of toxicity up to 5 years is under 1%and up to 10 years is under 2%, but rises to nearly 20% after 20 years. A 71-year-old arthritic white woman requested a second opinion regarding retinal Plaquenil toxicity. The patients history was significant for seronegative rheumatoid arthritis diagnosed 6 years prior. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects.

    While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula.

    Retinal toxicity from plaquenil years after discontinued

    Is Damage Still Occurring? - Review of Optometry, Retinal toxicity secondary to Plaquenil therapy Request PDF

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  6. Retinal Damage. According to, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg.

    • Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis..
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    A sharp increase in the prevalence of retinal toxicity is noted following five to seven years of medication use. 6 Newer literature emphasizes the risk of cumulative dosing that occurs over a period of time 1,000g rather than the previous suggestion of 6.5mg/kg of body weight. Thus, annual screening is recommended after five years for non-high risk patients. Retinal toxicity from Plaquenil is of serious concern because even after cessation of the drug there is little if any visual recovery, and sometimes a progression of visual loss over several years after the drug has been stopped. Fortunately, retinal toxicity from plaquinil is quite rare relative to the number of individuals taking the medication. Another speculation, based on the macular localization of the toxicity, is that light absorption or cone metabolism may play a role in its effect. 1 Clearance of the drug from blood and urine can take months to years after discontinuation, and a few patients have shown continued toxicity years after hydroxychloroquine treatment was stopped. 3

  7. BobRU New Member

    The middle-aged woman who came in for an appointment told me that another doctor had prescribed hydroxychloroquine (Plaquenil) to help her with symptoms of Raynaud’s disease. Hydroxychloroquine Tablets - FDA prescribing information. Hydroxychloroquine Plaquenil RheumTutor Stay Safe When Your Drug Is Off-Label - Consumer Reports
  8. stevens09 XenForo Moderator

    Warning for non-medical redditors: Chloroquine is promising, but it's possible to OD on it and cause blindness among other things, especially if you have certain genetics. Is anyone researching that, or are any of the regions fighting the outbreak trying that proactively? Chloroquine Oral Route Proper Use - Mayo Clinic Chloroquine Dosage Guide with Precautions - Chloroquine Oral Uses, Side Effects, Interactions, Pictures.
  9. Guest

    Hydroxychloroquine Plaquenil Success, Reviews and Side Effects Hydroxychloroquine is an antimalarial drug used to prevent and treat malaria. Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus.

    Hydroxychloroquine MedlinePlus Drug Information