False-negatives and false-positives from immunoassays can lead to adverse consequences for patients and providers. By identifying medications that contribute to false-negatives and false-positives, pharmacists decrease misinterpretations from urine drug screens. Trametinib and hydroxychloroquine Treating psoriatic arthritis with plaquenil False-positive results for methadone, opioids, phencyclidine, barbiturates, cannabinoids, and benzodiazepines were also reported in patients taking commonly used medications. The most commonly. Used to treat ADHD, Ritalin is a well-known cause of false positive tests for amphetamine, methamphetamine, and LSD. 12 Doxylamine. Doxylamine, found in Unisom and other over-the-counter sleep aids, may cause a false positive on drug tests for methadone, opiates, or PCP. 13 Sertraline Zoloft Sertraline is an antidepressant. Taking Sertraline could lead to a positive result for benzodiazepines or LSD on a drug test. In addition, there are any number of other metabolites with unknown cross-reactivities that also might contribute to a false MDN2 immunoassay signal. In practice, this means a urine sample of a person taking vortioxetine but not methadone can test positive for methadone and negative for vortioxetine. Pharmacists can provide guidance in selecting appropriate drug therapies that are less likely to cause false readings, thus decreasing the need for additional testing. Unexpected results from urine immunoassays should have a confirmatory gas chromatography–mass spectrometry or a high-performance liquid chromatography test performed. Plaquenil false positive methadone False Positive for Methadone -, Medications That Can Cause a False Positive on Drug. Amoxicillin and plaquenilPlaquenil toll like endosomal If the methadone is certain to have been ingested, and the proper urine is certain to have originated from the donor, then indeed a positive methadone, negative metabolite would be an interesting find. I would hope that the donor would accept to this testing to clear the air and allow for the validation of his claims. Dr. Luckow Methadone positive, no methadone metabolites - Occupational Medicine Forum. Vortioxetine use may cause false positive immunoassay results for urine.. Ask the Expert False Positive Amphetamine Urine Screens. A false positive drug test means that one gets a positive result for the drug but in reality, they didn’t take it. One might be wondering how it is possible for to test positive if one haven’t taken any drugs. However, it’s quite possible. And studies suggest false positive test results occur in 5 to 10% of the total cases. Bentyl® - false positive for LSD, Methadone Benylin - false positive for Opioids Benzedrine® - Amphetamines Benzphetamine - false positives for Amphetamines, Ecstasy, and LSD Biphetamine® - for Amphetamines Black Pearls Tung Sheuh pills - contain benzodiazepines Briantum - may test positive for benzodiazepines False-positive opiate tests have reportedly been caused by dextromethorphan, diphenhydramine, quinine, quinolones, rifampin, verapamil, and poppy seeds.4 In the hopes of testing for medical adherence, some urine drug screens specifically include methadone. Of note, false positive methadone screens have been reported to be caused by quetiapine.