Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine lysosome blocker Sensorineural hearing loss and plaquenil Hydroxychloroquine and pregnancy Chloroquine dna transfection A complete ophthalmologic examination is recommended before starting or within the first year of starting hydroxychloroquine therapy. During this exam, patients should receive a fundus examination; visual fields and spectral-domain optical coherence tomography SD-OCT should be added if maculopathy is present. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. Repeat 10-2 HVF testing demonstrated the dense paracentral scotomas. SD-OCT showed loss of the parafoveal inner/outer segment junction, thinning of the parafoveal outer nuclear layer, and a loss of the normal foveal depression, which is characteristic for hydroxychloroquine retinal toxicity Figure 3. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct test for plaquenil New Plaquenil Guidelines, Protecting your eyesight when taking Plaquenil Lupus. Malaria prophylaxis with chloroquine Before beginning treatment with plaquenil, the doctor will perform a baseline eye examination and the following tests Dilated Retinal Examination, Retinal Photography, Visual Field Test, OCT. The risk of developing retinopathy increases with the length of time plaquenil has been taken and the dosage prescribed. Plaquenil Eye Exams - Catalina Eye Care. Hydroxychloroquine Plaquenil Toxicity and.. Multimodal Imaging in Plaquenil Toxicity. The AVISE HCQ test is available as a venous test and via a AVISE ® Touch low volume capillary device test. Clinical Utility The AVISE HCQ test is intended for use in patients on hydroxychloroquine PLAQUENIL therapy, after steady state approx. 90-120 days, to help assess the following Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. When treating lupus or arthritis, tell your doctor if your symptoms do not improve after 6 months of treatment. Before taking this medicine. You should not use Plaquenil if you are allergic to hydroxychloroquine. Plaquenil is considered a mild medicine for RA and is often used as a first-choice medicine. The main problem with plaquenil is that it can affect your vision. So everybody on plaquenil must do at least a field vision test once a year, and is recommended to do additional tests like OCT test.