The most commonly used DMARD is methotrexate (Trexall®, Rheumatrex®, Otrexup®, Resuvo®). Other DMARDs include sulfasalazine (Azulfidine®), leflunomide (Arava®), hydroxychloroquine (Plaquenil®), Cyclosporine (Neoral®, Sandimmune®), Azathioprine (Imuran®), and Apremilast (Otezla®). Can plaquenil cause kidney problems Plaquenil liver toxicity Low dose of plaquenil Among those who were on leflunomide, four were on a single drug while one also received methotrexate. Both patients in the other group were on methotrexate and hydroxychloroquine. The onset of neuropathy was on an average 3 months range 45 days to 120 days after the initiation of leflunomide. Fuerst and co-workers noted the risk of postoperative wound healing complications in patients undergoing leflunomide therapy was significantly higher than in patients undergoing alternative treatments with methotrexate.17 These authors reported a 40.6 percent complication rate in patients undergoing leflunomide therapy in comparison to a 13.6. The study is based on leflunomide and hydroxychloroquine sulfate the active ingredients of Arava and Plaquenil, respectively, and Arava and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. This prevents some cells in your body from reproducing themselves. Methotrexate works by blocking enzymes that help DNA (genetic material in the cells of your body) form or repair. Leflunomide methotrexate and hydroxychloroquine The Combination of Leflunomide Arava and Methotrexate is Safe., A Guide To Perioperative Management Of The Rheumatoid Patient. Hydroxychloroquine redditPlaquenil tamoxifen toxic symptomsCan hydrocodone and hydroxychloroquine be taken together Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Leflunomide, a disease-modifying anti-rheumatic drug DMARD. Leflunomide, Sulfasalazine and Hydroxychloroquine for Rheumatoid.. Arava and Plaquenil drug interactions - eHealthMe. Methotrexate or Arava? -. Yet, its beneficial/negative effect on the metabolic complications associated with cardiovascular disease prominent in RA patients is still unravelled. Objectives To analyze and compare the effects of methotrexate, leflunomide and hydroxychloroquine on the obesity and insulin resistance in an obese collagen-induced arthritis CIA mouse model. Leflunomide is a new drug with a different mechanism of action than other DMARDs such as methotrexate, antimalarial drugs chloroquine and hydroxychloroquine, sulfasalazine, gold, azathioprine, d. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid.