One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine diphosphate salt msds Plaquenil toxicty Plaquenil and easy bruising Plaquenil treatment for vasculitis Sep 15, 2014 Retinal toxicity associated with chronic exposure to hydroxychloroquine and its ocular screening. is the most important risk for toxicity, an editorial from 2012. Similar to the 24-2 and 30-2 visual fields, where the central 4 degrees are affected by Plaquenil toxicity, the area of risk on a 10-2 is two degrees to six degrees from center. 19 Due to the inevitability of missed subtle defects, deviation plots should be reviewed Research has shown that your risk of developing retinopathy is higher the longer you are taking Plaquenil. In fact, the incidence of retinal toxicity rises sharply in people that have taken it between 5 and 7 years. As a result, baseline testing should occur within the first year of taking the drug and then annually at the five-year mark. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Risk of plaquenil toxicity Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, How to Succeed in Plaquenil Screenings Chloroquine phosphate toxic to bacteriaPlaquenil sante canadaBenign shin tumor and plaquenil The risk may be much higher because retinopathy can be detected earlier when using more sensitive screening techniques. OBJECTIVES To reassess the prevalence of and risk factors for hydroxychloroquine retinal toxicity and to determine dosage levels that facilitate safe use of the drug. The risk of toxic retinopathy in patients on long-term.. Plaquenil Side Effects on Your Eyes and Vision. New Plaquenil Guidelines. Aug 29, 2014 Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. The longer you use the medication, the higher the risk of toxicity. In addition to dosage, long duration of HCQ usage can put patients at higher risk for developing retinal toxicity. Other risk factors, such as underlying maculopathy, renal disease and use of.