Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil and tick bites Hydroxychloroquine contraindications Hydroxychloroquine sulphate tablets ip Plaquenil back pain and headache The subjective component to HCQ retinopathy screening is an automated visual field testing the central 10° of vision. The earliest signs of HCQ retinopathy on a central visual field may present as a cluster of paracentral points with decreased sensitivity. These points may be only mildly depressed. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. HCQ is cleared by the kidneys and thus renal disease increases the risk of toxicity. Therefore, both dosage and screening frequency may need to be adjusted. Tamoxifen use used in breast cancer treatment increases the risk of toxicity approximately 5 fold 8. The mechanism of this linkage is not understood. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil eye testing PATIENT FACT SHEET Hydroxychloroquine Plaquenil, Plaquenil Risk Calculators Expired chloroquine still goodDoes plaquenil affect your sleep Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. How to Succeed in Plaquenil Screenings. Hydroxychloroquine Plaquenil Toxicity and.. Study Finds Blood Levels of Plaquenil may be Important Indicator of Eye.. The doctors of Wellish Vision Institute are experienced in testing patients for early signs of Plaquenil side effects. Thorough tests include visual acuity examinations, distortion and color vision tests, central field of vision tests, and a detailed dilated retinal exam. If signs of abuse or side effects are detected. The management of patients on plaquenil has been a controversial subject. Alot of the concerns are related to the problems caused by chloroquine, the predecesor to hydroxychloroquine Plaquenil. It was much more toxic to the retina and much more likely to cause permanent visual problems. At San Antonio Eye Specialists, we monitor Plaquenil patients by testing visual acuity, color vision, central visual field testing, distortion test and a thorough retina exam. If signs of retinopathy are detected, the drug is stopped and vision typically returns to normal. In some cases, vision is permanently affected.