Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Chloroquine indication Chloroquine dose rheumatoid arthritis What can i take for heartburn with plaquenil Is plaquenil an immunosuppressant medication They never could figure out why. I was on CellCept at the time, but I was still on it when they stopped, so who knows. As for the liver, well I'm dealing with the same thing. I've got elevated liver enzymes currently. They told me I just have a fatty liver, and that it could actually be because of my Prednisone. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Liver enzymes are present in liver cells and are spilled out into the bloodstream when there is an injury or illness to the liver. According to the Mayo Clinic, the two most common liver enzymes that are released and tested for are alanine transaminase, or ALT, and aspartate transaminase, or AST. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Plaquenil and liver enzymes Elevated liver enzymes in Plaquenil how severe and when., Plaquenil Side Effects Common, Severe, Long Term - Can plaquenil cause headaches Elevated liver enzymes are a common problem in some patients being treated with hydroxychloroquine, such as patients with lupus. However, as a general rule, hydroxychloroquine is not associated with an elevation in liver enzymes when used to treat autoimmune and rheumatologic diseases. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Rheumatoid Arthritis & Elevated Liver Enzymes Healthfully. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Can plaquenil cause liver damage. Premium Questions. loss of appetite, vomiting, clay colored feces, Lab tests showing raised liver enzymes, bilirubin. Plaquenil is one of the most frequently used preventative measures for the issue. Plaquenil lowers the levels of 1,25D and therefore calcium in the blood at a moderate rate. To bring down calcium levels more quickly prednisone is used, and may even be used in an IV form for sick patients brought into the ER. Fluids to rehydrate may be necessary. Core tip The existence of liver disease associated with lupus itself, or increased susceptibility to concomitant liver diseases, either autoimmune or non-autoimmune ones, is still somewhat controversial, and difficult to diagnose. Data in the literature are scarce, and often based on case reports or clinical studies with limited patient size or histological evidence.