Additionally, another exception occurred while executing the custom error page for the first exception. This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. What is plaquenil used for in lupus Chloroquine and fluoroquinolone dissertation How does plaquenil cause blindness Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. METHODS A prospective and continuing evaluation was made of the potential retinal toxicity of hydroxychloroquine in a cohort of 360 Greek patients followed for RA and SLE, 58 of whom have received long term treatment six years. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. Plaquenil retinal toxicity treatment Chloroquine and Hydroxychloroquine Toxicity Treatment., Plaquenil Side Effects Common, Severe, Long Term - Clinical trials cancer chloroquineHydroxychloroquine sulfate dosage for lupusGray nails and plaquenilGetting off hydroxychloroquine Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Retinal toxicity in long term hydroxychloroquine treatment.. Retinal toxicity secondary to Plaquenil therapy.. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Patients suffering from chloroquine and hydroxychloroquine retinal toxicity were referred for study. All of the studies were carried out between 19, giving a 30-year experience. This is a retrospective study of these patients. The patient population included three cases of chloroquine and 26 cases of hydroxychloroquine retinal toxicity. Retinal toxicity is a very rare side effect of the hydroxychloroquine therapy, but when it has occurred, vision loss may be permanent and may progress even years after the cessation of medication. Patients would be examined every 3 months, then annually, until they are stabled.