Clinical trials cancer chloroquine

Discussion in 'Canada Drug' started by Deadangel, 19-Mar-2020.

  1. F1eryG User

    Clinical trials cancer chloroquine


    Listing a study does not mean it has been evaluated by the U. One of the mechanisms responsible for survival of these therapy-resistant hypoxic cells is (macro-)autophagy: a phenomenon in which cells provide themselves with energy (ATP) by digesting their own cell-organelles. Tumor hypoxia is a well-known factor negatively influencing outcome in many solid tumors, including small cell lung cancer.

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    Clinical trials are research studies that involve people. The clinical trials on this list are for colon cancer treatment. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer CUBiC The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Adjuvant Effect of Chloroquine on Gemcitabine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government.

    Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy.

    Clinical trials cancer chloroquine

    Chloroquine & Hydroxychloroquine supporting chemo., A Phase 2 Randomized, Double-blind Trial Evaluating the.

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  4. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy.

    • Chloroquine as an Anti-Autophagy Drug in Stage IV Small Cell..
    • Adjuvant Effect of Chloroquine on Gemcitabine - Full Text..
    • The clinical value of using chloroquine or hydroxychloroquin..

    The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. Clinical trials repurposing lysosomotropic chloroquine CQ derivatives as autophagy inhibitors in cancer demonstrate encouraging results, but the underlying mechanism of action remains unknown. Here, we report a novel dimeric CQ DC661 capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine. The potential of metformin and chloroquine as adjuvant drugs was recently demonstrated in vivo, where metformin or chloroquine had a sensitising and/or synergistic antitumour effect in combination with temozolomide,39 40 cisplatin41 42 and gemcitabine43 44 in xenograft models or proof-of-concept clinical trials of various types of human cancer.

     
  5. -Garik- New Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine Sulfate - Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine Medicare Coverage and Co-Pay Details - GoodRx
     
  6. searchers9 New Member

    Hydroxychloroquine Plaquenil Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness.

    Diarrhea, Fever and Skin rash Common Related Medical.