It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil tablet image Is plaquenil dangerous People on plaquenil Chloroquine metabolism Although it does not have an official FDA pregnancy classification, Aralen chloroquine phosphate is generally considered a pregnancy Category C medication. Some animal studies indicated that the drug might increase the risk of miscarriages, eye damage, and other problems. The editorial alludes to chloroquine as "yet another drug which is apparently toxic to the developing fetus." In the 20-year period that chloroquine has been available, it has been used by an estimated 1 billion people—by the armed forces of the United States, the armed forces of other nations, and the populations in malarious areas. The authors found significant intrasubject variability in serum HCQ during pregnancy 11. Twenty-four percent of patients had at least 1 HCQ level 100 ng/ml, suggesting a high rate of nonadherence. Among the SLE pregnancies, those with nontherapeutic levels of HCQ 100 ng/ml. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Chloroquine pregnancy category Primaquine Oral Uses, Side Effects, Interactions, Pictures., Safety of Chloroquine in Pregnancy JAMA JAMA Network Plaquenil and age spots It appears to be safe for use during pregnancy. Chloroquine is a member of the drug class 4-aminoquinoline. It works against the asexual form of malaria inside the red blood cell. Chloroquine was discovered in 1934 by Hans Andersag. Chloroquine - Wikipedia. Too Little of a Good Thing Hydroxychloroquine in Pregnancy.. Hydroxychloroquine Use During Pregnancy. The change in recommendations is based on the recent Food and Drug Administration FDA re-categorization of mefloquine from a pregnancy category C drug to category B, based on their review of the published data on mefloquine use during pregnancy. Answer Pregnant women should avoid travel to malaria-endemic areas if possible. However, if travel cannot be avoided, measures to prevent mosquito bites, along with an effective chemoprophylaxis regimen, should be implemented. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Nov 25, 2019 Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm.