Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Ati hydroxychloroquine Malaria proguanil and chloroquine Chloroquine in hepatic dysfunction Hydroxychloroquine sulfate and hydroxychloroquine sulfate plaquenil SLE and present an overview of indications for use, phar-macology, mechanisms of action and potential toxicity of these drugs. Pharmacology of hydroxychloroquine and chloroquine Hydroxychloroquine is very similar to chloroquine except for the addition of a hydroxyl group to the side chain and b-hydroxylation of the N-ethyl substituent. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. Lupus Systemic Lupus Erythematosus or SLE Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine mechanism of action in sle Chloroquine - Wikipedia, Hydroxychloroquine DermNet NZ Pictures of chloroquine tabletsHydroxychloroquine pulmonary toxicityPlaquenil generic approval datePlaquenil package insert Mechanism of Action Unknown; may interfere with with macrophage presentation of antigen to T cells Contraindications Hypersensitivity to hydroxychloroquine, chloroquine, or 4-aminoquinolines Precautions Use caution in hepatic disease, psoriasis, and porphyria. Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Hydroxychloroquine decreases Th17-related cytokines in.. Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis RA, systemic lupus erythematosus SLE and other. Medical use. Hydroxychloroquine treats malaria, systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever. In 2014, its efficacy to treat Sjögren syndrome was questioned in a double-blind study involving 120 patients over a 48-week period. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Mechanism of Action. Chloroquine exerts its antimalarial effects by preventing the polymerization of heme into hemozoin a food source for the malarial parasite. Chloroquine forms a drug-hemozoin complex, and this complex caps the polymerizing chain, thereby preventing additional polymerization.