Please review the following URL and make sure that it is spelled correctly. This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Plaquenil visual side effects Hydroxychloroquine immunosuppressant Hydroxychloroquine off label uses Is hydroxychloroquine an anti inflammatory Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Uncontrolled eye movements unsteadiness, trembling, or other problems with muscle control or coordination vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. Hydroxychloroquine eye issues Hydroxychloroquine toxicity - EyeWiki, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Phototherapy and plaquenil combinationPlaquenil serious side effectsChoi et al 2014 chloroquine paclitaxelChloroquine phPlaquenil for pmr Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. If you do, your risk of eye problems will. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. The Risk of Retinal Toxicity with Plaquenil. End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision. Recent studies have shown that patients of Asian descent develop initial damage in a more peripheral extramacular distribution near the arcades, most frequently in the inferotemporal region with corresponding superonasal field defects. Initially retinal toxicity due to long-term use of chloroquine Aralen for malaria was reported in 1959 by Hobbs et al. 106 Currently, hydroxychloroquine sulphate Plaquenil is the quinoline agent of choice for the treatment of autoimmune diseases with a far lower incidence of adverse reactions. 107, 108 Hydroxychloroquine has been associated with many ocular toxic effects including keratopathy, ciliary body dysfunction, lens opacities, outer retinal damage, and pigmentary retinopathy. Since the hydroxychloroquine can’t penetrate the fat tissue that means there is a higher concentration of it in sensitive tissues like the retina. People with kidney and liver problems have a tougher time eliminating the drug from their system so they are at higher risk because the body is going to retain more of the drug for a longer period of time.