She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Chloroquine phosphate uk Hydroxychloroquine 12.5mg Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. MONITORING FOR PLAQUINIL-INDUCED RETINAL TOXICITY Plaquenil is used for the treatment of malaria, systemic lupus erythematosus, rheumatoid arthritis, and other inflammatory and connective tissue diseases. Retinal toxicity from Plaquenil is of serious concern because even after cessation Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Plaquenil toxicity monitored with New Plaquenil Guidelines, Hydroxychloroquine-Induced Retinal Toxicity - American. Chloroquine side effectsPlaquenil increased gasMalaria chloroquine resistant areasCan u smoke on hydroxychloroquine Patients with any of the aforementioned findings are considered “high risk” and should be monitored closely. 2011 Testing Guidelines. Since the initial screening and monitoring recommendations were published in 2002, there have been reports of retinal toxicity associated with the use of Plaquenil. New Plaquenil Guidelines -. MONITORING FOR PLAQUINIL-INDUCED RETINAL TOXICITY. Plaquenil - Uses, Side Effects, Interactions -. Ocular Surgery News The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients. Plaquenil hydroxycholoroquine is a medication used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions. It is very effective and the risk of damage to the eye is very low the first five years if the patient is receiving the recommended dose and does not have special risk factors like kidney damage. Concomitant PLAQUENIL and digoxin therapy may result in increased serum digoxin levels serum digoxin levels should be closely monitored in patients receiving combined therapy. Insulin or antidiabetic drugs As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required.