As a result, the body produces antibodies that inflict cell damage, most commonly targeting joints, skin, kidneys and the nervous system. I think even though they say it doesn't make a difference, I feel wierd if I don't take my plaquenil sometimes. Hi want2bepainfree, If you don't have to, don't stop your plaquenil. No one knows but I cry sometimes when no one is around to see me. Hugs, Mel Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. Join the group and find support for coping with lupus. I stopped taking the plaquenil the beginning of December. And when I'm crying like a baby--I could feel the pain just throb in me. I took plaquenil for several years, then I went to the Mayo Clinic and they didn't think I had lupus and took me off. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. Plaquenil and intestinal problems Best way to monitor patients for plaquenil Hydroxychloroquine human antihimeric antibodies Nov 12, 2009 Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. Answer. I would opt for slowly tapering it unless you are having some sort of side effect and need to be off of it quickly. Even if your arthritis and skin psoriasis are quiet, you may flare. tapering it slowly would allow you to continue methotrexate or substitute another agent. Discuss with your doctor. It doesn't agree with my stomach (I take it with meals too). The pain in my swollen neck glands is horrific, and my arms and legs are hurting once again. Why does it seem like my whole life just turned for the worst --it was like I was fine one day and the next I'm so ill. It was pure hell, every joint in my body hurt and the fatigue was tremendous. As Tracy stated it is such as slow acting drug when you first start it, it's really hard to tell if it's working, it's not until we stop the med that we realize what a huge difference it was making. I happen to run out of my medication and fail to be in a hurry to get a refill because I had convinced myself that it wasn't working anyway. I missed 2 doses and felt a lot of pain in my arms, and had a pretty bad couple of days. Just wondering if any of you experience any pain if you don't take a few pills. Can you stop hydroxychloroquine cold turkey Can I quit Abilify cold turkey? - Quora, Lupus Medicines Hydroxychloroquine - Brigham and Women's. Can drink if i using hydroxychloroquineDose of chloroquine at 4 0 yearPlaquenil side effects increased appetitie Jun 19, 2013 Guys, Are there side effects to stopping Plaquenil? If so, what? How soon after do you feel the effects of Sarcoidosis? Michele. Side effects to Stopping Plaquenil. - Sarcoidosis - Inspire. Quitting Methotrexate Cold Turkey - Arthritis Information. Alcohol Withdrawal Cold Turkey Dangers. Your infection may not clear up if you stop using the medicine too soon. For patients taking hydroxychloroquine to prevent malaria Your doctor may want you to start taking this medicine 1 to 2 weeks before you travel to an area where there is a chance of getting malaria. This will help you to see how you react to the medicine. May 07, 2012 Saturday was a week since I stopped taking Plaquenil, aka Hydroxychloroquine, per my doctor's instructions, and I think I am going through some form of withdrawal. I took the drug as a treatment for sarcoidosis and one of the side effects is a reduction in white blood cells, which is what has happened to me. Aug 26, 2016 He said that I could stop plaquenil cold turkey. It slowly decreases effectiveness in the body. After the holidays, I am tempted to stop to see if the symptoms of lupus reappear so he can diagnose me.