My rheumatologist is running tests but thinks I have a mixed connective tissue disease. I noticed plaquenil helping with my fatigue more so than anything else. I just want some relief from the knee, shoulder and wrist pain. It does help my joint pain but I need extra help from other meds too It can take up to 6 months to get in your system and fully work, each person is different. Plaquenil sulfate Does plaquenil cause weight gain or loss Citalopram and hydroxychloroquine Can plaquenil cause extreme fatigue Plaquenil is a drug that is used to treat malaria infections. It also happens to have immunosuppressive properties and is used to limit inflammation. Arthritis is a disease that is characterized by pain secondary to joint inflammation. This patient stated that the plaquenil was working great and her joint pain had been reduced tremendously. Plaquenil and Joint pain - a study from real-world data. Summary Joint pain is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. Plaquenil was great for the pain and swelling but did almost nothing for the fatigue. I actually have found nothing for fatigue. Of all the meds, Plaquenil was the best for me and helped the most, but some people don't tolerate it. If it does not help the joint pain be sure to talk to your doctor, there are other meds they can give you to help. From what I understand, it is "the first line of defense" and definitely worth a try! I pray it doesn't take that long for you to get some relief. Plaquenil was great for the pain and swelling but did almost nothing for the fatigue. Of all the meds, Plaquenil was the best for me and helped the most, but some people don't tolerate it. Plaquenil joint pain Plaquenil Side Effects Common, Severe, Long Term -, Will you have Joint pain with Plaquenil - eHealthMe Plaquenil and lovenoxHydroxychloroquine eliminationMorrowind aralen ancestral tombPlaquenil immune system Aug 29, 2014 In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias joint pain, dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” The Risk of Retinal Toxicity with Plaquenil. Plaquenil for joint pain -. Plaquenil and pain" Rheumatoid Arthritis Community.. I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. I've been on plaquenil for 6 months now and I still have significant joint pain! I can't say that the drug has helped at all, but it is difficult to compare todays pain with that of 6 months ago. Hydroxychloroquine Plaquenil – American College of Rheumatology – It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.