Affecting my self esteem Your definitely not alone. I’m fair hair n skin but I’m getting brown blotches. I am not looking to when it starts coming down my face hope I can b helped in time. Plaquenil causing psoriasis Hydroxychloroquine and skin hardening Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil comes in 200 milligram mg tablets that are taken by mouth. To prevent malaria in adults, two tablets are typically taken once a week, on the same day each week. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. My scalp has turned black and my forehead side of face r slowly turning ears r totally black shiny plate .various long and boring treatments from docs but to no avail.finally I have been asked to stopped taking h for lupus for 3 next step will b decided. I am surprised to hear about this cos my rheumy said hydroxy helps to lighten the skin. One of them is on my nose and people keep telling me I’ve a dirt mark. I'm from Indian sub continent and am a "woman of colour like urself" approx 2 years ago had sudden deep painful itch in scalp and body. Yes I have been on this med since 2003 and I have black patches all over. Plaquenil dark spots Plaquenil and skin discoloration - Sjogren's World, Plaquenil Hydroxychloroquine - Side Effects, Dosage. What is hydroxychloroquine sulphate used forPlaquenil side effects eye testsPlaquenil to treat lyme diseaseChloroquine cutaneous lupusPlaquenil pour psoriasis I have been on Plaquenil for two years for RA, for which it has been great apart from a bit of itchiness, which I've mentioned elsewhere on this site in reply to another member asking about this. But lately the skin on my arms looks a bit blotchy. By this I mean that there are numerous small whiter-coloured circles whiter than the surrounding skin, anyway, almost like scars, or rather like. Plaquenil and 'white patches' on my skin? - Inspire. Plaquenil & skin discoloration -. Hydroxychloroquine and skin darkening Hi All. - LUPUS UK. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Plaquenil Reviews. She mentioned that Plaquenil can cause brown blotchy spots on skin. I've been on Plaquenil 4 months and I have noticed some brown spots on my face. I had no idea what they were and was going to see a Dermatologist. Each white-to-off-white, film-coated, peanut-shaped tablet with "PLAQUENIL" in black on one side contains 200 mg of hydroxychloroquine sulfate equivalent to 155 mg of base. Nonmedicinal ingredients black ink, calcium hydrogenophosphate, carnauba wax, corn starch, magnesium stearate, opadry White YS-I-7443, and polyethylene glycol 400.